Precautionary Measures
Refer to the Warning section for additional information.
Prior to commencing amitriptyline treatment, inform your healthcare provider or pharmacist about any known allergies to it, other tricyclic antidepressants (such as nortriptyline), or any other allergies you may have. This product might contain inactive ingredients that could trigger allergic reactions or other adverse effects. Consult your pharmacist for further clarification.
Before initiating this medication, disclose your medical history to your healthcare provider or pharmacist, particularly if you have a history of bleeding disorders, respiratory issues, liver complications, recent heart attacks, urinary problems (e.g., due to an enlarged prostate), hyperthyroidism, glaucoma (specifically angle-closure type), mental health conditions (such as bipolar disorder, psychosis), a family history of suicide, seizures, or conditions that heighten the risk of seizures (such as other neurological disorders or alcohol withdrawal).
Amitriptyline usage may lead to a heart rhythm disorder known as QT prolongation. This condition, although rare, can result in serious (and rarely fatal) rapid or irregular heartbeat, along with other symptoms like severe dizziness or fainting, necessitating immediate medical attention.
The risk of QT prolongation may be exacerbated by certain medical conditions or concurrent use of drugs that can prolong QT intervals. Before starting amitriptyline, inform your healthcare provider or pharmacist about all medications you’re taking and whether you have any of the following conditions: specific heart conditions (heart failure, bradycardia, QT prolongation on EKG), or a family history of such heart conditions (QT prolongation on EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also heighten the risk of QT prolongation. This risk can increase with the use of certain medications (such as diuretics or “water pills”) or conditions like excessive sweating, diarrhea, or vomiting. Discuss with your doctor about safely using amitriptyline in such circumstances.
This medication may induce dizziness, drowsiness, or blurred vision. Alcohol or marijuana (cannabis) consumption may intensify these effects. Refrain from driving, operating machinery, or engaging in activities requiring alertness or clear vision until you can do so safely. Avoid alcohol consumption. Consult your doctor if you are using marijuana (cannabis).
Before undergoing surgery, ensure your doctor or dentist is aware of all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements.
This medication may increase your skin’s sensitivity to sunlight. Limit exposure to the sun, avoid tanning beds and sunlamps, and use sunscreen and protective clothing when outdoors. Notify your doctor promptly if you experience sunburn or skin redness/blistering.
For individuals with diabetes, this medication may affect blood sugar control. Monitor your blood sugar levels regularly and inform your doctor of the results. Adjustments to your diabetes medication, exercise regimen, or diet may be necessary.
Elderly individuals may be more susceptible to the side effects of this medication, including bleeding, dry mouth, dizziness, drowsiness, confusion, constipation, difficulty urinating, and QT prolongation (as mentioned above). Dizziness, drowsiness, and confusion can elevate the risk of falls.
During pregnancy, use this medication only when absolutely necessary, after discussing the risks and benefits with your doctor.
Since untreated mental health conditions (such as depression, anxiety, panic disorder) can be serious, do not discontinue this medication unless instructed by your doctor. If you are planning pregnancy, become pregnant, or suspect pregnancy, promptly discuss the risks and benefits of using this medication during pregnancy with your doctor.
This medication passes into breast milk, and its effects on nursing infants are uncertain. Consult your doctor before breastfeeding.
See also:
What Is a Pap Smear?: Meaning, Test Results & Preparations
Acyclovir: Usage, Reactions, Precautions & Overdose
Abilify: Usage, Reactions, Precautions and Additional Information
